The River Clyst is a river of England. The river runs through the county of Devon.
Rising near the village of Clyst William near Cullompton, the river runs west and southwest, flowing through the settlements of Norman's Green, Plymtree, Clyst Hydon, Clyst St. Lawrence, Westwood, emerging in the Clyst Valley.
From there, the river goes southward through Broadclyst, West Clyst, Clyst Honiton, Clyst St. Mary and Clyst St. George, eventually flowing into the Exe estuary at Bowling Green Marsh, immediately south of the port of Topsham near Exeter.